Digestibility assay showed that Cry1B.868 and  Cry1Da_7 were rapidly digested by pepsin and pancreatin within 0.5 and 5 minutes, respectively. Acute oral gavage was also performed on mice, which showed that the observable adverse effect level (NOAEL) for for both proteins was at 5000 mg/kg body weight. Treatment-related effects on animal survival, clinical signs, body weight gain, food consumption or gross pathology were also not observed. Additionally, the bioinformatic analyses of the protein sequence showed no relevant structural similarity to known allergens or toxins. Based on these relevant information, the assessors fond sufficient scientific evidence that Corn MON 95379 is as safe as its  conventional counterpart and shall not pose any significant risk to human and animal health.